Scoring of Matrix Gla protein (MGP) promoter variants within predicted transcription elements

Background: Matrix Gla protein (MGP) is known as a calcium scavenger within sub-endothelial space of vessels, so that its function is suggested to reduce the risk of coronary artery diseases. In this study, we predicted the role of MGP promoter rs1800801, rs1800802 and rs1800799 variants on the score changes of predicted transcription elements. Methods: The gene promoter fragments flanking the polymorphic positions were selected from Ensembl Genome browser. The transcription elements containing wild polymorphic positions were found on the alignment with Jaspar profiles (similarity >80). Then, the changes of scores were statistically tested on the polymorphic modifications within the elements. Results: The scores had not significant differences on the changes of the rs1800801, rs1800802 and rs1800799 alleles within the predicted elements (P=0.69, P=0.87 and p=0.07, respectively). Discussion: The prediction results showed that the allele changes within the elements could not significantly affect the transcription factor scores.